引用大鼠ELISA科研检测试剂盒的文献（大鼠elisa试剂盒说明书）

引用大鼠ELISA科研检测试剂盒的文献

文献收集：

Epimedium

引用大鼠ELISA科研检测试剂盒的文献（大鼠elisa试剂盒说明书）

AqueousExtract

AmelioratesCerebral

Ischemia/ReperfusionInjury

throughInhibitingROS/NLRP3-

MediatedPyroptosis

引用试剂盒：

种属:大鼠

IL-1β(RJ15465),IL-18(RJ15463),TNF-α(RJ16622),IL-6(RJ15478),IL-10(RJ15453),iNOS(RJ16565),MDA(RJ15503),ROS(RJ15780),CAT(RJ15737),SOD(RJ16691),GSHPx(RJ25745),LDH(RJ16172)

IF：7.675

Abstract:

Cerebralischemia/reperfusioncausesexacerbatedneuronaldamageinvolvingexces

siveneuroinflammationandoxidativestress.ROSisconsideredasignalmoleculetoactivate

NLRP3;thus,theROS/NLRP3/pyroptosisaxisplaysavitalroleinthepathogenesisofcerebralis

chemia/reperfusioninjury(CIRI).Therefore,targetingtheinhibitionoftheROS/NLRP3/pyroptosis

axismaybeapromisingtherapeutictacticforCIRI.

Epimedium

(EP)containsmanyactiveingredients

(ICA,ICSII,andICT),whichhaveawiderangeofpharmacologicalactivities.However,whether

EPcanprotectagainstCIRIremainsunknown.Thus,inthisstudy,wedesignedtoinvestigate

theeffectandpossibleunderlyingmechanismofEPonCIRI.Theresultsshowedthattreatment

withEPdramaticallymitigatedbraindamageinratsfollowingCIRI,whichwasachievedbysup

pressingmitochondrialoxidativestressandneuroinflammation.Furthermore,weidentifiedthe

ROS/NLRP3/pyroptosisaxisasavitalprocessandNLRP3asavitaltargetinEP-mediatedprotection.

Mostinterestingly,themaincompoundsofEPdirectlybondedwithNLRP3,asreflectedbymolec

ulardocking,whichindicatedthatNLRP3mightbeapromisingtherapeutictargetforEP-elicited

cerebralprotection.Inconclusion,ourfindingsillustratethatICSIIprotectsagainstneuronlossand

neuroinflammationafterCIRIbyinhibitingROS/NLRP3-mediatedpyroptosis.